Yes. macOS has native USB driver support. If you want to write files to it, ensure the drive is formatted as exFAT (not NTFS, which is read-only on Mac).
The Ultra Flair may come with SanDisk SecureAccess preloaded on the drive. This software creates a password-protected 256-bit AES encrypted folder on your flash drive. sandisk ultra flair usb 3.0 driver download
No. SanDisk does not include driver CDs. The only preloaded files are SecureAccess and a user manual PDF. sandisk ultra flair usb 3.0 driver download