For a solo freelancer, no. For a SOC handling 500+ alerts daily, the math works. Using the free API, you might spend 4 seconds per alert. Using Premium automation, you reduce that to 0.2 seconds. If an analyst costs $50/hr, the API pays for itself in saved overtime within two months.
Once you have the key (a 64-character alphanumeric string), you stop using the web UI and start using curl , Python, or Go. The endpoint changes from www.virustotal.com to www.virustotal.com/api/v3/ .
If you use a free key on a Premium endpoint, you get a 403 Forbidden . With the Premium key, you get enriched data. (Free users get a hash; Premium users can download the sample if it is part of their subscription).