To understand the demand for Proteus VX on Mac, we must understand what the software offered. Released roughly around 2007–2008, Proteus VX was a virtual instrument powered by the E-MU Production Tools Software. It was essentially a software wrapper for the sound engine found in the Proteus 2000 series hardware.
If the technical hurdles of running Proteus VX are too high, consider these native Mac alternatives: EMU PROTEUS VX won't load as VST. - PG Music Forums
, though this often resulted in high latency or stability issues. Notable Features of the Software Emu Proteus VX VST - free download
Wine is a compatibility layer that allows Windows applications to run on Unix-based systems like macOS.