If the setup for SAI 2 feels like too much work, these apps are built for macOS and offer that same lightweight, "SAI-like" feel: Can you run sai 2 on an apple computer? : r/PaintToolSAI

If you have an older Mac with an Intel processor, you can use the built-in Boot Camp Assistant

Wine or CrossOver attempt to run Windows apps directly without a full OS. This can be difficult to set up, and users often report bugs or lack of pressure sensitivity.

If you have an older Intel-based Mac, you can use Boot Camp to install Windows on a separate partition. This provides the best performance but requires you to restart your computer every time you want to switch from macOS to your drawing setup. Top Native Mac Alternatives to Paint Tool SAI 2

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For most artists, running a virtual machine is too much hassle just to draw. If you are looking for a because you want a lightweight, intuitive art program that feels like SAI, you should look at native Mac alternatives.

However, there is a persistent, frustrating catch for a massive segment of the digital art community: There is no official macOS version.

Created by a former SAI user, Paintstorm is lightweight and highly customizable. It runs natively on Mac and includes every SAI brush feature plus animation tools.

Older Macs with Intel chips can use Apple's Boot Camp to dual-boot into Windows. This gives the program full hardware power but requires restarting your computer to switch systems. Recommended Native Mac Alternatives