Polyspecific Anti-Human Globulin (AHG) reagent typically contains:A) Anti-IgG and Anti-IgMB) Anti-IgG and Anti-C3dC) Anti-IgM and Anti-C3bD) Anti-IgA and Anti-C3d
A group O patient with a history of multiple transfusions requires an emergency transfusion. The antibody screen is positive, and the identification panel reveals Anti-Jka. All Jka-negative units are O positive. However, the patient types as Group O, Rh negative. What is the best course of action?
A) 21 daysB) 35 daysC) 42 daysD) 5 days
– Kidd antibodies are notorious for "fading," which can lead to dangerous delayed hemolytic transfusion reactions if a patient's history is unknown. Multiple Choice Questions And Answers In Immunohematology
Explanation: Cell 1 (DCe) has E negative; Cell 2 (DcE) has E positive; Cell 3 (dce) has E negative. Anti-E reacts with E-positive cells (Cell 2) but not E-negative cells.
This is often caused by cytokines or recipient antibodies reacting to donor white blood cells.
Which of the following is true regarding Kidd blood group system antibodies?A) They are destroyed by enzymesB) Titers can quickly drop to undetectable levels in patientsC) They never cause delayed hemolytic transfusion reactionsD) They react best at room temperature However, the patient types as Group O, Rh negative
A) D antigenB) A antigenC) H antigenD) B antigen
In an emergency situation when there is no time for a full crossmatch, a trauma patient with no prior transfusion history is O-positive. You issue O-positive uncrossmatched blood. What is the residual risk? a) Immediate acute hemolytic reaction due to ABO incompatibility. b) Development of anti-D in the patient. c) Possible delayed hemolytic reaction due to Kidd antibodies from donor plasma. d) No risk because O-positive is the universal donor.
Explanation: Anti-I is a cold agglutinin (usually IgM) that reacts best at 4°C – RT, but typically weakens/disappears at 37°C. Anti-M can also be cold-reactive, but Anti-I is the classic mycoplasma pneumoniae -associated cold agglutinin. The key: Immediate spin (RT) positive, 37°C negative. Explanation: Cell 1 (DCe) has E negative; Cell
– Polyspecific AHG is designed to detect both IgG antibodies and complement components (specifically C3d) coating red cells.
Immunohematology is used in transfusion medicine for a variety of purposes, including blood typing, cross-matching, and antibody screening. These tests help to ensure the safe and effective transfusion of blood products to patients.
Immunohematology is a complex and fascinating field that plays a critical role in transfusion medicine. The multiple choice questions and answers provided in this article help to assess knowledge and understanding of immunohematology. By mastering the concepts of immunohematology, healthcare professionals can ensure the safe and effective transfusion of blood products to patients.