When Trissel says "No information" or your scenario involves 3+ drugs, call your hospital’s IV compatibility pharmacist or use a physical lab test (visual inspection after mixing a small sample).
Standardized as drug amount per liter.
Chemotherapy drugs are highly reactive (e.g., platinums, taxanes). Incompatibility with antiemetics or hydration fluids can precipitate the chemo, under-dosing the patient and causing local toxicity. Trissel is mandatory in oncology pharmacy. handbook on injectable drugs trissel
| Feature | Print (Purple Spiral) | Digital (e.g., ASHP or ClinicalKey) | | :--- | :--- | :--- | | | Always | Only with download | | Search speed | Slow (use the index) | Instant (CTRL+F) | | Updates | Every 2–3 years | Real-time / annual | | Sticky notes & tabs | Yes (classic pharmacy style) | No | | Cost | ~$250–350 one-time | Subscription (~$50–100/year) |
Compatibility when mixed in a single syringe. When Trissel says "No information" or your scenario
Based on the significance and impact of the Handbook on Injectable Drugs, the following recommendations are made:
An online database might flag "Y-site: Monitor." Trissel will tell you, "At room temperature, furosemide and milrinone form a precipitate within 15 minutes when mixed in a 1:1 ratio in saline." That distinction saves lives. Based on the significance and impact of the
First published in 1977, the Handbook on Injectable Drugs is a comprehensive, evidence-based reference that tells you the physical and chemical compatibility of intravenous drugs.
The Handbook on Injectable Drugs, often referred to as "Trissel's" and published by the American Society of Health-System Pharmacists (ASHP) , serves as the global standard for information on the compatibility and stability of parenteral medications. It provides over 360 detailed monographs backed by extensive research, aiding pharmacists and clinicians in assessing drug interactions and proper administration techniques. For more details on the 19th edition, visit ASHP.
The Handbook on Injectable Drugs is not just a book—it is a commitment to scientific rigor and patient safety. Respect the data.