Notably, the team has support for all 32-bit PCI memory cards manufactured before 2012. These models will be removed from the samtool supported models list in version 4.2, scheduled for January 2026.

curl -X POST https://api.samtool.io/v1/check-model -d '"model":"MZQL23T8HCLS-00A07"'

You can load any fine‑tuned SAM checkpoint as long as it follows the original state_dict keys or SAM2’s configuration schema.

used to run these models, or perhaps how Samtools compares to in variant calling? Sequence Alignment/Map Format Specification - Samtools

As of early 2026, the tool has expanded support for dozens of new models, including:

Always verify your model against the official matrix before running any destructive Samtool commands. And if your hardware isn’t listed, remember: forcing compatibility is far more expensive than waiting for an update.