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| Aspect | Details (from the literature) | |--------|------------------------------| | | A heterocyclic compound, often described as a 4‑(5‑fluoro‑1H‑indazol‑3‑yl)‑N‑(2‑pyridyl)‑benzamide (or similar). The exact IUPAC name can vary between papers, but the core scaffold is a fluoro‑substituted indazole linked to a pyridine‑containing benzamide. | | Typical use | Reported as a selective inhibitor of the protein kinase JAK‑3 (Janus Kinase 3) and, in some studies, as a probe for JAK‑STAT signaling in immune cells. | | Biological activity | - IC₅₀ ≈ 30‑50 nM against JAK‑3 in enzymatic assays. - Shows >10‑fold selectivity over JAK‑1, JAK‑2, and TYK2. - Demonstrated anti‑inflammatory effects in vitro (e.g., reduced IL‑2 production in activated T‑cells). | | Research context | Frequently cited in medicinal‑chemistry and pharmacology papers focused on immunomodulation , autoimmune disease models , and structure‑activity relationship (SAR) studies of indazole‑based kinase inhibitors. | JUFE-443
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Design, synthesis and biological evaluation of a novel JAK‑3 inhibitor JU‑443 Journal: Journal of Medicinal Chemistry (2022) | | Typical use | Reported as a
is a production code from the Japanese adult media industry, specifically associated with the studio . It features the performer Erika Ozaki